Interrupting seasonal transmission of bilharzia and control of intestinal worm infections in northern and central Côte d’Ivoire

Conditions

Schistosoma haematobium infection Infections and Infestations Schistosoma haematobium infection

Mamadou Ouattara, Fidèle K. Bassa, Nana R. Diakité, Jan Hattendorf, Jean T. Coulibaly et al. (13 authors)

Clinical Infectious Diseases2021-09-1315 citations

Molecular characterization and distribution of Schistosoma cercariae collected from naturally infected bulinid snails in northern and central Côte d’Ivoire

Yves-Nathan T. Tian-Bi, Bonnie L. Webster, Cyrille K. Konan, Fiona Allan, Nana R. Diakité et al. (16 authors)

Parasites & Vectors2019-03-1961 citations

10.1186/s13071-019-3381-3

Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Côte d'Ivoire: a SCORE study protocol.

Tian-Bi YT, Ouattara M, Knopp S, Coulibaly JT, Hürlimann E, Webster B, Allan F, Rollinson D, Meïté A, Diakité NR, Konan CK, N'Goran EK, Utzinger J.

2018-01-2926 citations

10.1186/s12889-018-5044-2

Interventions

The study will take place in 60 villages of northern and central Côte d’Ivoire. The 60 villages are randomly assigned to four study arms (15 villages per arm). Arm A: Villages receive

before, during and shortly after peak transmission) In all study arms, participants complete surveys are completed among three population cohorts (i.e. up to 50 children aged 5-8 year

100 children aged 9-12 years and 50 adults aged 20-55 years) at baseline, 1, 2 and 3 years.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Children, females and males, aged 5-12 years 2. Adults, females and males, aged 20-55 years 3. Resident in one of the 60 villages in northern and central Côte d’Ivoire that are part of the study 4. Written informed consent signed by adults (aged 20-55 years) and parents/guardian of children (aged 5-12 years) and oral assent by children 5. Able and willing to provide single urine and stool samples during the annual cross-sectional surveys 6. No known allergy to study medication (i.e. praziquantel)

Exclusion criteria

Exclusion criteria: 1. Children not aged 5-8 years or 9-12 years 2. Adults not aged 20-55 years 3. No written informed consent by adults, and parents/guardian on behalf of their children 4. Pregnancy in female participants 5. Known allergy to study medication (i.e. praziquantel)

Design outcomes

Primary

Measure	Time frame
Prevalence and intensity of S. haematobium infection is assessed using the standard urine filtration method and microscopy at baseline, 1, 2 and 3 years.	—

Secondary

Measure	Time frame
1. Snail abundance and infection rates are assessed using malacological surveys (i.e. searching for intermediate host snails by hand and with scoops for 15 min in a defined area of a natural open freshwater body) in arm 4 only at baseline, 1, 2 and 3 years 2. Presence and number of intestinal helminth eggs will be assessed with the Kato-Katz method at baseline, 1, 2 and 3 years	—

Countries

Cote d'Ivoire, England, Switzerland, United Kingdom

Outcome results

None listed