Measuring biomarkers using aptamers

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN10920454

Enrollment

309

Registered

2024-05-17

Start date

2022-05-09

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Different physiological states (e.g. phases of menstrual cycle e.g. follicular, pre-ovulatory, luteal phase) and endocrine conditions (e.g. Cushing’s syndrome, Addison’s disease, Acromegaly, Hypothalamic Amenorrhoea, Polycystic Ovary Syndrome). Nutritional, Metabolic, Endocrine

Interventions

This prospective single-centre observational study aims to investigate aptamer-based biomarker measurement and assess the ability of aptamer-based sensors to detect and measure biomarkers. Study par

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged =18 years old 2. Either no current medical condition OR a current medical condition that can be diagnosed or monitored using biomarkers

Exclusion criteria

Exclusion criteria: 1. History of medical, psychological or other conditions, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study results to make them no longer useful or could potentially result in harm to the participant. 2. History of blood donation within the past 3 months, or the intention to do so within 3 months of completing the study.

Design outcomes

Primary

Measure	Time frame
1. Biomarker levels in biological fluid(s) measured using the aptamer device via intermittent sampling compared with biomarkers measured in blood using standard laboratory assay methods, both for up to 720 minutes during Visit 1 and up to 5 other study visits in healthy volunteers and patients with a medical condition that can be diagnosed or monitored using biomarkers. 2. Production of normative ranges for biomarkers measured using the novel aptamer device (at different times of the day, e.g. 0800-1000, 1200 and 1700) in healthy volunteers in different physiological states (e.g. the follicular, pre-ovulatory and luteal phases of the menstrual cycle) and people with endocrine conditions (e.g. Cushing’s syndrome, Addison’s disease, Acromegaly, hypothalamic amenorrhoea, polycystic ovary syndrome).	—

Measure

Time frame

1. Biomarker levels in biological fluid(s) measured using the aptamer device via intermittent sampling compared with biomarkers measured in blood using standard laboratory assay methods, both for up to 720 minutes during Visit 1 and up to 5 other study visits in healthy volunteers and patients with a medical condition that can be diagnosed or monitored using biomarkers. 2. Production of normative ranges for biomarkers measured using the novel aptamer device (at different times of the day, e.g. 0800-1000, 1200 and 1700) in healthy volunteers in different physiological states (e.g. the follicular, pre-ovulatory and luteal phases of the menstrual cycle) and people with endocrine conditions (e.g. Cushing’s syndrome, Addison’s disease, Acromegaly, hypothalamic amenorrhoea, polycystic ovary syndrome).

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

England, United Kingdom

Contacts

Public ContactChioma Izzi-Engbeaya

c.izzi@imperial.ac.uk+44 (0)20 3313 3242

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Sep 19, 2026