Bone proteins in the treatment of periodontal diseases

Evaluation of the effectiveness of recombinant human bone morphogenic protein 2 (rhBMP-2) in combination with bioresorbable membrane (PLA/PGA) for periodontal regeneration in grade II furcation defects: a clinical study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN10907678

Enrollment

Registered

2022-11-06

Start date

2019-01-26

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Regenerative periodontal therapy in the management of furcation defects caused due to periodontal diseases Oral Health

Interventions

After achieving adequate anesthesia, intra-crevicular incisions were given on the buccal surfaces of teeth, including one tooth adjacent (mesial and distal) to access the furcation defect for treatmen

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Grade II furcation defects 2. Furcation defects present in mandibular 1st molars 3. Systemically healthy 4. Furcation defects present on the buccal surface

Exclusion criteria

Exclusion criteria: 1. Grade II furcation defects in second mandibular molars 2. Patients with past history of periodontal therapy 3. Former and current smokers

Design outcomes

Primary

Measure	Time frame
1. Relative clinical attachment level measured using Williams graduated periodontal probe and numerical values were recorded into a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively 2. Vertical probing depth measured using Williams graduated periodontal probe and numerical values were recorded into a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively 3. Horizontal probing depth measured using Nabers graduated furcation probe and numerical values were recorded into a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively 4. Relative gingival margin level measured using Williams graduated periodontal probe and numerical values were recorded in a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively	—

Measure

Time frame

1. Relative clinical attachment level measured using Williams graduated periodontal probe and numerical values were recorded into a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively 2. Vertical probing depth measured using Williams graduated periodontal probe and numerical values were recorded into a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively 3. Horizontal probing depth measured using Nabers graduated furcation probe and numerical values were recorded into a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively 4. Relative gingival margin level measured using Williams graduated periodontal probe and numerical values were recorded in a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively

—

Secondary

Measure	Time frame
Periodontal regeneration was assessed by clinical attachment gain, vertical probing depth reduction and horizontal probing depth reduction which were measured using Williams graduated periodontal probe and numerical values were recorded into a Microsoft Excel spreadsheet at baseline, 3 months and 6 months postoperatively	—

Countries

India

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026