Positive blood culture Haematological Disorders
Conditions
Interventions
A total of 150 patients are planned to be enrolled in the study, randomly allocated with a 2:1 ratio into two groups (group A: 100 patients included in the study group with molecular testing BCID2 and
Sponsors
bioMérieux SSC Europe Sp. z o. o.
4th Military Clinical Hospital in Wroclaw
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Positive blood culture will be eligible for the study 2. Two sets of blood (2x aerobic, 2x anaerobic) 3. Age >18 years 4. Informed consent form to participate in the study
Exclusion criteria
Exclusion criteria: 1. Age under 18 years 2. Refusal to participate in the study 3. Positive blood culture for the 72 hours follow-up (ex. for Staphylococcus aureus bacteriemia). 4. Patients with blood PCR tests ordered outside the established research protocol and the established randomization. (PCR test ordered by the attending physician due to the patient's severe condition). * in our hospital, the doctor can order a PCR test from blood on his own in the case of a patient in a life-threatening condition, in shock, or for other reasons. Such patients will not be eligible for our study. They may constitute an interesting group of patients in the future, which can be compared with group A planned by our team, where, in addition to the blood PCR test, consultations will be provided on the correct treatment with the appropriate selection of ATB as well as the dosage and duration of treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Time to optimal antimicrobial therapy [Time Frame: 21 days] Calculated from the time of blood culture draw to the laboratory to the time the optimal antimicrobial therapy is started. Optimal antimicrobial therapy is defined based on hospital guidelines. | — |
Secondary
| Measure | Time frame |
|---|---|
| Measured using patient records unless indicated: 1. Time to organism identification [Time Frame: 7 days] Calculated from the time of blood culture draw to the time of organism identification. 2. Time to effective antimicrobial therapy [Time Frame: 14 days] Calculated from the time of blood culture draw to the time the effective therapy is started. Effective therapy is determined based on the susceptibilities of the organism. 3. Infectious -cause mortality [Time Frame: 30 days] 4. Length of hospital stay [Time Frame: 30 days] 5. Episodes of Clostridioides dificille [Time Frame: 30 days] 6. Intensive care unit days [Time Frame: 30 days] 7. Time to De-escalation from brad-spectrum therapy to the targeted agent [Time Frame: 7 days] 8. Time to Discontinuation of the therapy due to the identification organism being a contaminant [Time Frame: 14 days] | — |
Countries
Poland
Contacts
Public ContactPatrycja Lesnik
Outcome results
None listed