Lung cancer Cancer
Conditions
Interventions
Patients who meet the study inclusion criteria who attend outpatient cancer care clinics at Newcastle upon Tyne Hospitals NHS Foundation Trust will be identified by members of the study team. They wil
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 and over 2. Able to provide written informed consent to participate in the study 3. English speakers 4. Body weight within minimum and maximum scanner requirements of 50-100 kg 5. Diagnosed with non-small cell lung cancer by the clinical team 6. Planned to receive radical OR high dose palliative radiotherapy (+/- adjuvant chemotherapy or surgery)
Exclusion criteria
Exclusion criteria: 1. Patients below the age of 18 years 2. Patients who are not able or decline to give informed consent to participate in the study 3. Non-English speakers 4. Body habitus incompatible with positioning within the MRI scanner sensor used for 19F-MRI (approximately equivalent to a body circumference > 120cm at chest height, and body mass index > 35 kg/m²) 5. Pregnant or breastfeeding 6. MRI contraindications: incompatible implanted medical device (e.g. cardiac pacemaker), or metallic implants incompatible with MRI 7. Claustrophobia incompatible with MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The percentage of ventilated lung volume (%VV) measured using fluorine MRI study data to characterise the extent of lung ventilation defects in the lungs of lung cancer patients before radiotherapy (single scan, baseline) at one time point | — |
Secondary
| Measure | Time frame |
|---|---|
| Regional tracer gas wash-in and wash-out rates measured using the fluorine MRI scan, and clinical lung function measured using spirometry at baseline | — |
Countries
United Kingdom
Contacts
Public ContactResearch Activity Co-ordinator and Study Co-ordinator
Outcome results
None listed