Effects of different forms of coconut on lipid profile

Effect of different forms of coconut on the lipid profiles of healthy free-living Sri Lankan subjects

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10859733

Enrollment

200

Registered

2023-09-08

Start date

2014-04-01

Completion date

Unknown

Last updated

2024-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lipid profile Nutritional, Metabolic, Endocrine

Interventions

A randomized, placebo-controlled, prospective clinical trial was conducted at the Institute of Medical Research (MRI), Colombo, Sri Lanka. Participants were recruited from a local advertisement displa

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers aged 25-60 years 2. Total cholesterol level =250 mg/dl 3. Triglyceride level =300 mg/dl 4. Not on any form of medication or on nutritional supplementation

Exclusion criteria

Exclusion criteria: 1. Total cholesterol level =250 mg/dl 2. Triglyceride level =300 mg/dl 3. On any form of medication or nutritional supplementation

Design outcomes

Primary

Measure	Time frame
1. Lipid profile (consisting of total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride concentrations) measured at baseline and after 4 and 8 weeks. Lipid profiles were done after 10 hours of mandatory fasting and FBS was done after 8 hours fast. 1.1. Total cholesterol, HDL-cholesterol and triglyceride concentrations measured in serum by a Roch/Hitachi Modular P Chemistry Analyzer (Mod P) 1.2. The cholesterol assay used the cholesterol oxidase/peroxidase (CHOD/POD) method 1.3. HDL cholesterol was measured by a direct non-precipitating method using polyethylene glycol-coupled cholesteryl esterase (PEG-modified enzyme) and cholesterol oxidase 1.4. Triglycerides were analyzed using the glycerokinase/glycerophosphate oxidase method after initial hydrolysis with lipoprotein lipase. LDL cholesterol was calculated using the Friedewald formula.	—

Measure

Time frame

1. Lipid profile (consisting of total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride concentrations) measured at baseline and after 4 and 8 weeks. Lipid profiles were done after 10 hours of mandatory fasting and FBS was done after 8 hours fast. 1.1. Total cholesterol, HDL-cholesterol and triglyceride concentrations measured in serum by a Roch/Hitachi Modular P Chemistry Analyzer (Mod P) 1.2. The cholesterol assay used the cholesterol oxidase/peroxidase (CHOD/POD) method 1.3. HDL cholesterol was measured by a direct non-precipitating method using polyethylene glycol-coupled cholesteryl esterase (PEG-modified enzyme) and cholesterol oxidase 1.4. Triglycerides were analyzed using the glycerokinase/glycerophosphate oxidase method after initial hydrolysis with lipoprotein lipase. LDL cholesterol was calculated using the Friedewald formula.

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Secondary

Measure	Time frame
Fasting blood sugar (FBS) and HbA1c measured using Abbott’s Diabetes Care FreeStyle Libre at baseline, after 4 weeks and 8 weeks	—

Countries

Sri Lanka

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026