African children’s oxygen administration and nutrition clinical trial

Conditions

Severe pneumonia Respiratory

Damalie Nalwanga, Elisa Giallongo, Victor Musiime, Sarah Kiguli, Peter Olupot Olupot et al. (14 authors)

Frontiers in Nutrition2025-06-06

10.3389/fnut.2025.1507360

Is fat mass a better predictor of 6-month survival than muscle mass among African children aged 6-59 months with severe pneumonia?

Nalwanga D, Musiime V, Kiguli S, Olupot-Olupot P, Alaroker F, Opoka R, Tagoola A, Mnjalla H, Mogaka C, Nabawanuka E, Giallongo E, Karamagi C, Briend A, Maitland K.

2024-09-301 citations

10.1186/s40795-024-00939-6

Nutritional supplementation in children with severe pneumonia in Uganda and Kenya (COAST-Nutrition): a phase 2 randomised controlled trial.

Kiguli S, Olupot-Olupot P, Hamaluba M, Giallongo E, Thomas K, Alaroker F, Opoka RO, Tagoola A, Oyella S, Nalwanga D, Nabawanuka E, Okiror W, Nakuya M, Amorut D, Muhindo R, Ayub Mpoya, Mnjalla H, Oguda E, Williams TN, Harrison DA, Rowan K, Briend A, Maitland K.

2024-05-145 citations

10.1016/j.eclinm.2024.102640

Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial.

Kiguli S, Olopot-Olupot P, Alaroker F, Engoru C, Opoka RO, Tagoola A, Hamaluba M, Mnjalla H, Mpoya A, Mogaka C, Nalwanga D, Nabawanuka E, Nokes J, Nyaigoti C, Briend A, van Woensel JBM, Grieve R, Sadique Z, Williams TN, Thomas K, Harrison DA, Rowan K, Maitland K.

2021-10-185 citations

10.12688/wellcomeopenres.17123.2

Interventions

The randomisation lists are prepared and kept at the ICNARC CTU, London. Opaque and sealed randomisation envelopes are used to allocate the study interventions. 1. Supplementary feeding for 56 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children enrolled in the COAST trial (ISRCTN15622505) who survive to 48 hours and are older than 6 months

Exclusion criteria

Exclusion criteria: Children with severe malnutrition (defined as mid upper arm circumference <11.5cm)

Design outcomes

Primary

Measure	Time frame
Mid-upper arm circumference (MUAC) measured by MUAC tape (supplied by UNICEF) at baseline and 90 days and/or as a composite with 90-day mortality	—

Secondary

Measure	Time frame
Re-admission to hospital will be defined as hospitalisation	—

Countries

Kenya, Uganda

Contacts

Public ContactEmmanuel Oguda

EOguda@kemri-wellcome.org+254417522063

Outcome results

None listed