Immunomodulation in smokers/non-smokers Haematological Disorders Immunomodulation in smokers/non-smokers
Conditions
Interventions
A blend of essential oils, at a total of 10%, in a carrier of unfragranced white lotion base.
Sponsors
Fragrantia Investments (Australia)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Participants are to be: 1. Aged 18-60 years 2. Male 3. Willing to comply with study protocols 4. The smokers must consume 10 cigarettes per day, and have done so for at least a year 5. The non-smokers must have never smoked
Exclusion criteria
Exclusion criteria: Factors resulting in exclusion include: 1. any significant medical problem or chronic illness including the findings on assessment of: a. Body mass index (BMI) >30 or twice per week) 8. Recreational drug use 9. Any acute illness or infection in the preceding 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alterations in the immune system indicators being measured will be estimated via a series of blood tests; the measures include in vivo changes in: 1. Complete blood count including leucocyte count and differential 2. Lymphocyte subset phenotype 3. Natural killer cell activity 4. Erythrocyte sedimentation rate (ESR) 5. C-Reactive protein: high sensitivity assay (hsCRP) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures include in vivo alterations in: 1. Lymphocyte cytokine production profile 2. Liver function tests 3. Urea, creatinine and electrolytes | — |
Countries
Australia
Outcome results
None listed