Oral ranitidine is effective in treating toddler's diarrhea

Short course of daily oral ranitidine versus probiotics as a novel effective treatment for toddler's diarrhea: a multi-centre, double-blind randomized controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10783996

Enrollment

120

Registered

2016-08-09

Start date

2016-07-30

Completion date

Unknown

Last updated

2022-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Toddler's diarrhea (chronic non-specific diarrhea of childhood) Digestive System Toddler's diarrhea (chronic non-specific diarrhea of childhood)

Interventions

Participants are randomised to one of three groups, using colour-coded envelopes. Ranitidine Group: Participants receive dissolvable tablets of ranitidine (3 mg/kg/day), administered

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age range of 1-3 years 2. Diarrhea lasting 3 weeks or more 3. Characteristic stooling pattern of toddler's diarrhea 4. Absence of pyrexia and signs of dehydration 5. Normal anthropometry 6. Normal findings on stool analysis, microscopy and culture

Exclusion criteria

Exclusion criteria: 1. Signs of dehydration 2. Presence of pyrexia 3. Abnormal anthropometry

Design outcomes

Primary

Measure	Time frame
1. Stool frequency is measured using care-giver's home observation/records on days 5, 10 and 30 2. Stool consistency is measured using care-giver's home observation/records on days 5, 10 and 30	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

Nigeria

Contacts

Public ContactIkenna Ndu

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 17, 2026