Use of probiotic yoghurt to prevent diarrhoea in critical care: A randomised double-blind, placebo-controlled trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10768531

Enrollment

192

Registered

2010-05-12

Start date

2008-10-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Generic Health Relevance and Cross Cutting Themes

Interventions

Patients will be randomised to receive either one sachet of VSL#3 or placebo twice daily via their nasogastric tube, or feeding gastrostomy/jejunostomy. Probiotic/placebo administration will continue

Eligibility

Inclusion criteria

Inclusion criteria: Not provided at time of registration

Exclusion criteria

Exclusion criteria: Not provided at time of registration

Design outcomes

Primary

Measure	Time frame
Diarrhoea: defined as more than 3 loose stools per day (Bristol stool chart grade 7)	—

Secondary

Measure	Time frame
Clostridium difficile associated disease: Clostridium difficile A or B toxin (CDT) positive stool sample	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026