Asthma Respiratory Asthma
Conditions
Interventions
Each child is randomly assigned to either the training group (asthma self-management education and physical activity training program) or the control group (asthma self-management education).
The se
Sponsors
China Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Children aged between 6 and 12 years 2. Diagnosis of mild asthma by a physician based on the criteria of asthma symptoms and medical history 3. Having a methacholine test dose (PD20) of 8 mg/ml or less 4. Able to read and write 5. Having a score on the Asthma Control Test = 20 indicated ‘‘well-controlled’’ asthma
Exclusion criteria
Exclusion criteria: 1. Any chronic disease, e.g. epilepsy, congenital heart disease, serious physical/psychiatric disorders, severe asthma, acute asthma exacerbations, obesity (body mass index above 95th percentile) 2. Children who had a regular exercise habit (who perform physical activity 3 or more sessions per week at moderate to vigorous intensity for 30 min or above) 3. Participating in any other clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effects of physical training measured using the lung function test, methacholine test, biochemical analysis (Cytokine assays and Lipoxin A4) and polysomnography at baseline and 12 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Anthropometric measures (weight, height, waist circumference and BMI Z-score) and demographic data (gender ratio, percentage of allergic rhinitis, duration of asthma history, age) are measured at baseline and 12 weeks 2. Pulmonary function is measured using spirometry and methacholine test at baseline and 12 weeks 3. Inflammatory biomarkers are measured using Bio-Plex Pro human Cytokine/Chemokine Panel kits (Bio-Rad) and the enzyme-linked immunosorbent assay (ELISA) at baseline and 12 weeks 4. Sleep quality is measured using polysomnography at baseline and 12 weeks | — |
Countries
Taiwan
Outcome results
None listed