Topic: Diabetes Research Network, Primary Care Research Network for England
Conditions
Interventions
Dietary Intervention, 40g/day resistant starch for weeks compared to matched placebo
Study Entry : Single Randomisation only
Sponsors
University of Surrey (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Males and Females, aged 20 - 65 years 2. Those with T2DM, that has been diagnosed for > 2 years, and 3. Are either diet / exercise controlled or on metformin treatment (or both), which has not been modified in 6 months. Target Gender: Male & Female; Upper Age Limit 65 years ; Lower Age Limit 20 years
Exclusion criteria
Exclusion criteria: 1. Those who control their diabetes by insulin or sulphonylureas 2. Those with an HbA1c >= 8.5 indicative of poor control 3. Those with certain medical conditions (for example heart disease, gastrointestinal disease, liver disease, type 1 diabetes or endocrine diseases) 4. Those know to suffer from claustrophobia or have metal implants as this would prevent Magnetic resonance spectroscopy (MRS) scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 11. Glycaemic control 1.1. Hyperinsulinaemic clamp with stable isotopes 2. HbAc 3. Fasting glucose and insulin Measured at end of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ectopic fat distribution 1.1. Whole body magnetic resonance imaging (MRI) 2. Vascular function 2.1. Blood pressure and pulse wave analysis Measured at end of intervention | — |
Countries
United Kingdom
Outcome results
None listed