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Assessing the impact and effectiveness of alcohol care teams targeting adults with alcohol dependence admitted to NHS hospitals in England

Prospective pragmatic quasi-experimental study to assess the impact and effectiveness of alcohol care teams (ACTs) targeting adults with alcohol dependence admitted to NHS Hospitals in England: the ProACTIVE prospective patient study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN10723141
Enrollment
545
Registered
2023-11-01
Start date
2024-01-10
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol dependence Mental and Behavioural Disorders

Interventions

Current interventions as of 11/07/2025: This is a quasi-experimental study comparing patient outcomes from three hospital sites with optimal alcohol care teams (oACT) (based on the NHS England and N
therefore, a randomised controlled trial study design would not be appropriate for this research. Sample and sample size: A total of 545 current inpatients with a diagnosis of alcohol dependence will

Sponsors

University of Hull
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Adult aged >= 18 years 2. An ICD-10 diagnosis alcohol dependence as measured by CIDI-alcohol 3. Patient admitted to a participating hospital 4. Agrees to be contacted by the research team and participate in a follow-up interview at 6 months 5. Judged by clinical staff to be medically and psychologically fit enough to participate in the study 6. Willing and able to provide informed consent to take part in the trial

Exclusion criteria

Exclusion criteria: 1. Severe physical/mental illness likely to preclude active participation in baseline or follow-up interviews 2. Current participation in another research study 3. Unable to adequately understand verbal English due to the majority of the validated measures being available in English only 4. Currently prescribed opioid substitution therapy

Design outcomes

Primary

MeasureTime frame
Quantity of alcohol consumed is measured using the Timeline Follow-Back (TLFB)-28 day for alcohol at baseline and 6 months

Secondary

MeasureTime frame
1. Percent days abstinent from alcohol is measured using the Timeline Follow-Back (TLFB)-28 day for alcohol at baseline and 6 months 2. Quantity and type of substance used and percent days abstinent from each substance is measured using the Timeline Follow-Back (TLFB)-28 day for drugs at baseline and 6 months 3. Alcohol misuse is measured using the Alcohol Use Disorders Identification Test (AUDIT) at baseline and 6 months 4. Alcohol-related problems are measured using the Alcohol Problems Questionnaire (APQ) at baseline and 6 months 5. Severity of dependence is measured using the Severity of Dependence Questionnaire (SADQ) at baseline and 6 months 6. Mental health and wellbeing are measured using the Short Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS) at baseline and 6 months 7. Depressive symptoms are measured using the Patient Health Questionnaire (PHQ-9) at baseline and 6 months 8. Symptoms of anxiety are measured using the Generalised Anxiety Disorder scale (GAD-7) at baseline and 6 months 9. Health-related quality of life is measured using the EQ-5D-5L at baseline and 6 months 10. NHS and community resource use is measured using the Client Service Receipt Inventory (CSRI) at baseline and 6 months

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 4, 2026