Effect of lifestyle changes on metabolic health and PCSK9 levels in people with prediabetes

Lifestyle intervention improves metabolic parameters but does not modify PCSK9 levels in prediabetes: a prospective cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10701142

Enrollment

132

Registered

2026-04-23

Start date

2023-12-27

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prediabetes, insulin resistance, metabolic dysregulation Nutritional, Metabolic, Endocrine

Interventions

Lifestyle intervention consisting of individualized medical nutrition therapy and a structured exercise program. Dietary intervention included personalized caloric planning based on age, sex, and bod

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Adults aged 18–65 years 2. Confirmed diagnosis of prediabetes based on ADA criteria (HbA1c 5.7–6.4%) 3. Ability and willingness to comply with lifestyle intervention and follow-up assessments 4. Provision of written informed consent

Exclusion criteria

Exclusion criteria: 1. Diagnosis of type 2 diabetes mellitus 2. Use of lipid-lowering medications (including statins or PCSK9 inhibitors) 3. Chronic liver or kidney disease 4. Active infection or inflammatory disease 5. Malignancy 6. Pregnancy or lactation

Countries

Türkiye

Contacts

Public ContactYunus Saglar

yunussglr@gmail.com+90 5334518933

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 7, 2026