Remission of type 2 diabetes in overweight patients Nutritional, Metabolic, Endocrine
Conditions
Interventions
Patients aged 30-70 years attending hospital diabetes clinics who have had type 2 diabetes up to 5 years, and with Body Mass Index above 23 kg/m² will be invited to participate. Participants will be e
Sponsors
Kathmandu Medical College Teaching Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 30-70 years 2. Men and women 3. Type 2 diabetes of duration up to 4 years since diagnosis 4. Not insulin-dependent/type 1 diabetes 5. Body mass index >23 kg/m²
Exclusion criteria
Exclusion criteria: 1. Weight loss of >5 kg within the last 6 months 2. Pregnancy/lactation 3. MI or stroke in the past 3 months 4. Chronic pancreatitis, alcohol dependence, psychiatric illness and learning disability 5. Patients using insulin more than 30 units basal, or other complex insulin regimen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remission of type 2 diabetes (HbA1c <48 mmol/mol [<6.5%]) after 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Body weight measured with scales at 3, 6 and 12 months 2. HbA1c measured by standard laboratory method at 6 and 12 months 3. Blood pressure measured by electronic sphygmomanometer at 6 and 12 months 4. Microalbuminuria measured by dipstick and standard laboratory method at 6 and 12 months 5. Liver function tests measured by standard laboratory method at 6 and 12 months 6. Ultrasound liver fat measured at 6 and 12 months (if available) 7. Quality of life measured using WHO-BREF – QoL (Nepali version) at 6 and 12 months 8. Glucose-lowering and antihypertensive medications prescribed at 3, 6 and 12 months 9. Participant experience measured by qualitative interviews in a subset at different study stages | — |
Countries
Nepal
Outcome results
None listed