Eosinophilic esophagitis Digestive System
Conditions
Interventions
This will be a case-control feasibility study that collects faecal samples from patients undergoing diagnostic assessment or treatment for EoE, and from normal controls and controls of patients with o
Sponsors
Alder Hey Children's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: For EoE: Children attending endoscopy or clinic for known EoE or to investigate symptoms indicating flare-up of disease symptoms contacting the department, or patients found to have EoE who are awaiting treatment. For controls: Control patients identified in gastroenterology or ophthalmology outpatient clinics
Exclusion criteria
Exclusion criteria: 1. Patients unable to provide a faecal sample 2. Patients and parents unable to give informed consent 3. Previous colonic resection 4. Patients on an elemental diet unrelated to EoE 5. Current or treatment with systemic antibiotics in the previous 4 weeks 6. Patients with known chronic gastro-intestinal infection or chronic diarrhoea 7. Patients with confirmed and clinically significant irritable bowel syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patterns of volatile organic compounds associated with active EoE, measured using gas chromatography-mass spectrometry at baseline and 3 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Patterns of volatile organic compounds treated with medical (oral viscous budesonide) or dietetic (elimination diet) treatment, measured using gas chromatography-mass spectrometry at baseline and 3 months 2. Patient disease activity measured using Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) score at baseline and 3 months 3. Nutritional status and atopic background measured using Environmental questionnaire at baseline 4. Microbiome selected analysis and CGR (Centre for Genomic Research) sequencing of fecal sample at baseline and 3 months | — |
Countries
England, United Kingdom
Contacts
Public ContactMarcus;Chris Auth;Probert
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Outcome results
None listed