Oral lichen planus Skin and Connective Tissue Diseases
Conditions
Interventions
The study is divided into two phases: phase I consisted of topical treatment for 2 months
phase II was a six-month follow-up period without therapy. Patients are randomly divided into two groups. Randomization is performed using computer-generated random number tables. The first group of p
Sponsors
University of Turin (Italy)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histological diagnosis of OLP on the basis of WHO criteria: hyperkeratosis of the superficial epithelial layers, vacuolar degeneration of the germinative layer of the epithelium and band-like sub-epithelial lymphocytic inflammatory infiltrate 2. Presence of painful and atrophic-erosive oral lesions, at the same time with reticular ones 3. Ability to complete the present trial
Exclusion criteria
Exclusion criteria: 1. Presence of histological signs of dysplasia 2. Use of lichenoid reaction inducing drugs and presence of amalgam fillings close to lesions 3. Therapy for OLP in the 2 months prior to the study 4. Pregnant or breastfeeding women 5. Proved or suspected hypersensitivity caused by the tested chemicals
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain (visual analogue scale [VAS]) and clinical scores (Thongpranson scale) assessed at baseline, 4 weeks, 8 weeks, 20 weeks and 32 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time taken to reduce signs and symptoms during the first two weeks of treatment 2. Length of remission from signs and symptoms | — |
Countries
Italy
Outcome results
None listed