Preeclampsia Pregnancy and Childbirth Preeclampsia
Conditions
Interventions
Our research team will be notified by attending clinicians when there is a possible candidate for the biobank. A member of the research team will then see the candidate and will give them an informati
Sponsors
Stellenbosch University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Cases: 1.1. Women with a diagnosis of preeclampsia or severe preeclampsia in gestational week 20-42 1.2. Admitted to Tygerberg hospital Severe preeclampsia is defined as preeclampsia with an organ complication such as renal failure, pulmonary oedema, eclampsia, intracerebral hemorrhage, cerebral oedema, heart failure or disseminated intravascular coagulation 2. Controls: 2.1. Women with healthy pregnancies matched for gestational age admitted for delivery at Tygerberg hospital Both primiparous and parous women are included
Exclusion criteria
Exclusion criteria: 1. Cases: If the woman is not able to give informed consent 1.1. For women with pulmonary edema: Existing cardiac disease 1.2. For women with eclampsia: Existing neurological disease 2. Normotensive controls: 2.1. Pre-exisiting hypertension 2.2. Diabetes mellitus before or during pregnancy 2.3. Pre-exisiting cardiovascular, renal or cerebral disease 2.4. Chronic medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The items collected for the biobank include: 1. Specimens usually discarded during clinical care: E.g. placenta, placental membranes, umbilical cord, cord blood, urine, stool and cerebrospinal fluid (CSF). The CSF (maximum volume of 0.5 ml) will only be collected in women who are having spinal anaesthesia. We will collect the fluid that is usually discarded before the anaesthetic is injected 2. Blood samples: maximum of 12 ml at each collection time (usually only a single test tube of 5 ml). We will only collect samples if the patient is having blood taken for a clinical indication. We will collect blood up to a maximum of 6 times per participant 3. Saliva: This will be collected once in a 3 cc cup, 1-2 ml for freezing | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
South Africa
Contacts
Public ContactLina Bergman
Outcome results
None listed