Nutritional support algorithm for critically ill patients

Effectiveness of nutritional support algorithm on outcomes for critically ill patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10583582

Enrollment

350

Registered

2016-05-26

Start date

2016-05-05

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enteral feeding Nutritional, Metabolic, Endocrine

Interventions

This study is evaluating an enteral nutritional support algorithm. Critically ill patients are randomly allocated to one of two groups: 1. Those fed though the enteral nutritional support algorithm

and norepinephrine infusion rate <12.5 mcg/min 2. Then the gastrointestinal function is assessed and categorized as follows: 2.1. Normal function 2.2. Acute gastrointestinal injury grade 1-3 2.3. Con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Critically ill patients expected to stay in ICU for more than 3 days

Exclusion criteria

Exclusion criteria: 1. Previous EN within 7 days of current episode of ICU admission 2. Burn patients 3. Pregnancy and breast feeding 4. Patients with PEJ, PEG

Design outcomes

Primary

Measure	Time frame
28-day mortality	—

Secondary

Measure	Time frame
1. Incidence of ventilator associated pneumonia 2. Length of stay in ICU and hospital 3. Duration of mechanical ventilation 4. Biomarkers of nutritional status, including albumin, pre-albumin, chemistry profile, CD3, CD8, IgA, IgG, HLA-DR. They are measured via blood samples taken on a daily basis after enrollment into the study 5. Total amount of nutrition and the proportions of enteral and parenteral nutrition, measured by summing up calories intakes for the whole study period. Calories include enteral nutrition (commercial formula with fixed calorie per unit volume), and parenteral nutrition	—

Measure

Time frame

1. Incidence of ventilator associated pneumonia 2. Length of stay in ICU and hospital 3. Duration of mechanical ventilation 4. Biomarkers of nutritional status, including albumin, pre-albumin, chemistry profile, CD3, CD8, IgA, IgG, HLA-DR. They are measured via blood samples taken on a daily basis after enrollment into the study 5. Total amount of nutrition and the proportions of enteral and parenteral nutrition, measured by summing up calories intakes for the whole study period. Calories include enteral nutrition (commercial formula with fixed calorie per unit volume), and parenteral nutrition

—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 1, 2026