Prevention of cognitive decline in healthy elderly individuals at risk Mental and Behavioural Disorders
Conditions
Interventions
The assignment of participant to the groups will be made a posteriori, based on the learning success of the treatment. Therefore, it is a non-randomised controlled trial.
Participants will undergo do
Sponsors
National Autonomous University of Mexico
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy seniors aged 60 years or older 2. Right-handed 3. At least 9 years of formal schooling 4. IQ >80 (Shippley-2) 5. Normal Cognitive Assessment (MMSE >24) 6. Score of 1 or 2 in the Global Deterioration Scale 7. An excess of theta absolute power in at least one lead of their EEG (zPA[theta] > 1.96)
Exclusion criteria
Exclusion criteria: 1. History of psychiatric or neurological condition 2. Uncontrolled medical conditions such as hypertension, diabetes, thyroid dysfunction, hypercholesterolemia, anemia 3. General anesthesia in the year previous to enrollment in the study 4. History of cranioencephalic trauma with loss of consciousness 5. Use of drugs that are known to affect the EEG (e.g. benzodiazepines) 6. History of substance abuse (e.g. alcohol) 7. Presence of paroxysmal activity in the range of alpha frequencies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain electrical activity measured using qEEG. The measure of interest will be the z-value of the Theta/Alpha ratio. Measured before training, immediately after training and 3 months after training. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Brain electrical activity measured using qEEG: 1.1 Normative absolute power with geometric power correction of delta, theta, alpha and beta frequency bands in the 19 leads of the 10-20 international system referenced to linked earlobes before training, immediately after training and 3 months after training 1.2. Current Source Density distribution using e-LORETA before training, immediately after training and 3 months after training 2. Cognitive assessment: 2.1. Intelligence quotient and verbal comprehension, perceptual reasoning, working memory and processing speed indices measured using the Wechsler Adult Intelligence Scale (WAIS-IV) before training and 3 months after treatment. It is not possible to make the three timepoints evaluation due to the nature of the battery. 2.2. Attention and memory assessed using a neuropsychological battery standardized in Mexican population and with norms by age group and years of schooling (NEUROPSI-2) before training and 3 months after treatment. It is not possible to make the three timepoints evaluation due to the nature of the battery. 2.3. Executive functions assessed using a neuropsychological battery standardized in Mexican Population and with norms by age group and years of schooling (BANFE-2) before training and 3 months after treatment. It is not possible to make the three timepoints evaluation due to the nature of the battery. | — |
Countries
Mexico
Outcome results
None listed