Neurodegenerative diseases (Alzheimer's disease and related dementias (ADRD)
Conditions
Interventions
Study participants (persons with ADRD and PDAP) will be recruited from participating hospitals across the six geopolitical zones of Nigeria under the guidance of study neurologists. All dementia cases
Sponsors
Tertiary Education Trust Fund (TETFUND)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. ADRD or PDAP diagnosed based on standardized clinical research criteria (with or without corroborating additional diagnostic information) 2. Neurologically healthy volunteers
Exclusion criteria
Exclusion criteria: 1. Non-consent 2. Unable to complete clinical assessments due to disability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The association between each specified environmental risk factor documented in the Environmental Risk Questionnaire (ERQ) (residential history, smoking and tobacco, alcohol use, diet, occupation, toxicants, pesticides, caffeine, head injury, NSAID and calcium channel blocker use) and genetic polymorphisms in SNCA REP1 and APOE and ADRD and PDAP will be measured by comparing the presence of the risk factor compared in cases (dementia i.e. ADRD, and parkinsonism i.e. PDAP) and controls. Specifically, the study will report on: 1. Relative risk associated with specified environmental exposures in dementia versus healthy controls 2. Relative risk associated with specified environmental exposures in parkinsonism versus healthy controls 3. Hazard ratios comparing the frequency of APOE polymorphisms in cases (dementia and parkinsonism) and controls 4. Hazard ratios comparing the frequency of SNCA REP1 polymorphisms in cases (dementia and parkinsonisms) and controls. 1. Environmental risk exposure measured using Environmental Risk Questionnaire at baseline (enrolment) 2. Genetic variability in APOE and SNCA REP1 measured using genotyping for polymorphic variability/allele frequencies at baseline (enrolment) | — |
Secondary
| Measure | Time frame |
|---|---|
| Combined effects (gene-environment interactions) will be analysed by comparing the combined effects of all environmental risk factors and the genetic polymorphisms (measured at baseline [enrolment]) on the risk of dementia and parkinsonism. Computational analysis will be employed as the statistical method for data analysis. The outcomes will be reported as risk ratios. | — |
Countries
Nigeria
Contacts
Public ContactMoyinoluwa Olajide
Outcome results
None listed