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Does the application of fluoride varnishes during pregnancy induce changes in fluoride concentrations in the saliva of pregnant women?

Fluoride varnish effects in fluoride concentration in saliva throughout pregnancy: Longitudinal Clinical Randomized Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN10541688
Enrollment
80
Registered
2022-06-29
Start date
2019-09-01
Completion date
Unknown
Last updated
2022-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fluoride concentration in saliva in pregnant women Oral Health

Interventions

Pregnant women come to the Preventive Program recommended by their general practitioners. In the first visit, we take a sample of saliva before any procedure, then an oral exploration is made during w

Sponsors

University of Murcia
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Pregnant woman between 16 and 31 weeks of gestation 2. No abnormal syndromes found during gynecologist exploration 3. Willing to continue with the pregnancy 4. Pregnancy not classified as high risk 5. Acceptation of the informed consent 6. Pregnant women who speak and write the Spanish language properly 7. No mental disabilities

Exclusion criteria

Exclusion criteria: 1. Less than 15 weeks of pregnancy 2. More than 32 weeks of pregnancy 3. Abnormal syndromes found in the fetus 4. High-risk pregnancy 5. Women who have taken the decision to abort 6. Extreme difficulties to communicate 7. Patients with permanent orthodontic treatment

Design outcomes

Primary

MeasureTime frame
Fluoride concentration in saliva measured with a specific fluoride electrode, before the application of the varnish, immediately after, after 15 days, 30 days, and 45 days

Secondary

MeasureTime frame
1. Periodontal status, measured using the Community index of periodontal treatment needs (CPITN) over day 0, day 15, 30 and 45 2. Caries status, measured using the teeth with caries, absent because of caries or permanent teeth with fillings (CAOD) index over day 0, day 15, 30 and 45

Countries

Spain

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026