Developing a reproducible procedure for optimal utilization of platelet-rich plasma and platelet-rich fibrin in aesthetic treatments

Developing a reproducible procedure for optimal utilization of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in aesthetic treatments: efficacy evaluation using ultrasound imaging. Single-center prospective open-label randomized study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10538865

Enrollment

Registered

2024-01-22

Start date

2020-10-01

Completion date

Unknown

Last updated

2026-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Improving aging skin density and thickness by injecting different types of autologous plasma preparations. Other

Interventions

This study consists of two stages: a laboratory phase and a clinical phase. In the first stage, the laboratory tests aim to optimize the parameters (time and speed) of whole blood centrifugation, allo

Eligibility

Sex/Gender

Female

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Female volunteers 2. Aged between 30-60 years old 3. Seeking facial skin rejuvenation 4. Fitzpatrick skin types I to III and facial wrinkles classified as Glogau class II or higher

Exclusion criteria

Exclusion criteria: 1. Pregnancy or breastfeeding 2. Blood or platelet disorders 3. Facial surgery in the past year 4. Semi-permanent dermal fillers in the past year 5. Genetic conditions affecting fibroblasts or collagen 6. History of herpes simplex infection 7. Active skin diseases or infections in the treatment area 8. A tendency to develop hypertrophic scars or keloids 9. Immunosuppressive disorders or treatments 10. A history of skin cancer 11. Topical or oral tretinoin use 12. Undergone botulinum toxin and/or dermal filler injections, chemical peelings or laser treatments for facial rejuvenation in the past six months, or planned such treatments in the next six months

Design outcomes

Primary

Measure	Time frame
The density of the skin measured using ultrasound before starting the study and then one month after each treatment	—

Secondary

Measure	Time frame
1. The thickness of the skin measured using ultrasonographic images before starting the study and then one month after each treatment 2. The aesthetic improvement of the treated area self-measured by the subjects using the Global Aesthetic Improvement Scale (GAIS) one month after the third treatment 3. The level of personal satisfaction with the treatment measured using a questionnaire after completing the treatment	—

Measure

Time frame

1. The thickness of the skin measured using ultrasonographic images before starting the study and then one month after each treatment 2. The aesthetic improvement of the treated area self-measured by the subjects using the Global Aesthetic Improvement Scale (GAIS) one month after the third treatment 3. The level of personal satisfaction with the treatment measured using a questionnaire after completing the treatment

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Countries

Poland

Contacts

Public ContactLidia Majewska

drlmajewska@gmail.com+48 668508004

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 19, 2026