Understanding the link between gum disease and heart attacks Oral Health
Conditions
Interventions
Approximately 150 gum disease(periodontitis severe form of gum disease) subjects and 150 healthy volunteers (good gum health) will be approached once whilst attending a dental clinic for the managemen
Sponsors
University of Bristol
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: People with periodontitis: 1. All people over the age of 18 years 2. Capacity to consent 3. Attending a scheduled dental appointment at the University of Bristol Dental Hospital 4. People with unstable severe periodontitis or a high susceptibility to periodontitis ( as defined by the British Society of Periodontology 2019 implementation of the 2017 World Workshop Classification of periodontal and peri-implant diseases and conditions: Stage III/IV and Grade C. ) 5. At least 18 erupted teeth Healthy volunteers: 6. All people over the age of 18 years 7. Capacity to consent 8. Attending a scheduled dental appointment 9. People with no evidence of periodontitis 10. At least 18 erupted teeth
Exclusion criteria
Exclusion criteria: Exclusion criteria for people with periodontitis: 1. All people under the age of 18 years 2. Those who lack capacity to consent 3. History of cardiovascular disease such as hypertension, angina, previous myocardial infarction, heart failure, aortic disease, arrhythmia, heart valve disease. 4. History of autoimmune/autoinflammatory diseases such as Sjogren's syndrome, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, or systemic sclerosis 5. History of endocrine disease including diabetes mellitus types 1 and 2 6. Currently taking antibiotics or has had antibiotics in the preceding 6 months 7. People taking statins, non-steroidal anti-inflammatory medications, immunosuppressive medications or corticosteroids. 8. Smokers of tobacco (including Vaping/e-cigarettes) 9. History of salivary gland disease or oral mucosa disease Exclusion criteria for healthy volunteers: 10. All people under the age of 18 years 11. Those who lack capacity to consent 12. History of cardiovascular disease such as hypertension, angina, previous myocardial infarction, heart failure, aortic disease, arrhythmia, heart valve disease 13. History of autoimmune/autoinflammatory diseases such as Sjogren's syndrome, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, or systemic sclerosis 14. History of endocrine disease including diabetes mellitus types 1 and 2 15. Currently taking antibiotics or has had antibiotics in the preceding 6 months 16. People taking statins, non-steroidal anti-inflammatory medications, immunosuppressive medications or corticosteroids. 17. Smokers of tobacco (including Vaping/e-cigarettes) 18. History of salivary gland disease or oral mucosa disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behaviour of inflammatory blood cells (monocytes) will be measured using standard laboratory techniques including western blotting, specific enzyme-linked immunosorbent assays (ELISA), immunocytochemistry, fluorometry, and quantitative polymerase chain reaction at a single time point | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Biomarkers to assess a person’s risk for developing heart disease from saliva and blood samples measured using standard laboratory techniques including ELISA and western blotting. 2. Biomarker change following treatment of their gum disease measured using ELISA and other standard laboratory techniques assessing bloods/saliva before periodontal treatment (baseline) and following treatment (typically 6 months later) | — |
Countries
England, United Kingdom
Outcome results
None listed