Induced abortion Pregnancy and Childbirth Abortion
Conditions
Interventions
Four treatment groups:
A: Sublingual misoprostol every 3 hours
B: Sublingual misoprostol every 12 hours
C: Vaginal misoprostol every 3 hours
D: Vaginal misoprostol every 12 hours
Sponsors
UNDP/UNFPA/WHO/World Bank - Special Programme of Research, Development and Research Training in Human Reproduction
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Healthy women, eligible for and requesting medical abortion 2. Agrees to surgical termination should method fail
Exclusion criteria
Exclusion criteria: 1. Any indication of serious past or present illness 2. Allergic to misoprostol or with a strong allergic tendency in general 3. Heavy smokers (greater than 20 cigarettes a day) 4. With a scar in the uterus or cervix or any gynaecological anomaly detected with ultrasound 5. A history or evidence of mitral stenosis, glaucoma, or sickle cell anaemia 6. Diastolic blood pressure greater than 90 mmHg 7. Uncontrolled bronchial asthma 8. Systolic blood pressure less than 90 mmHg 9. History or evidence of thromboembolism or liver disease 10. Presence of an intrauterine device in utero 11. Haemolytic disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness, induction to abortion interval, side effects and acceptability. Approximate duration of involvement in the study for each subject: first follow-up at 15 days post-treatment, second follow-up (if required) at 42 days, subsequent follow-up as needed. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Armenia, Cuba, Georgia, India, Mongolia, Viet Nam
Outcome results
None listed