Colorectal cancer screening Cancer
Conditions
Interventions
The trial statistician calculated a randomization plan with varying block sizes and implemented it in the REDCap randomization module.
Intervention 1: Risk-based screening recommendations. Participan
Sponsors
Centre universitaire de médecine générale et santé publique, Lausanne
Eligibility
Sex/Gender
All
Age
50 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 50 and 74 years old 2. Residing in a canton whose screening center is recruiting for the trial 3. Having provided informed consent
Exclusion criteria
Exclusion criteria: People at very high risk of CRC or already up to date with screening are excluded. Specifically, those: 1. With current symptoms suspicious for colorectal cancer (i.e. rectal bleeding, unusual weight loss, etc.) 2. With a medical condition requiring colonoscopy surveillance at a shorter than 10-year interval 3. Having had a colonoscopy within 9.5 years or a FIT within 1.5 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Advanced colorectal neoplasia, defined as the proportion of participants with at least 1 of the following: adenoma > 1 cm; adenoma of any size with high-grade dysplasia; adenoma with villous or tubulovillous histology (=25% villous); serrated lesion > 1 cm; serrated lesion of any size with high-grade dysplasia; traditional serrated adenoma (any size); and, adenocarcinoma, measured using data collected from patient medical records, at 3-year follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are assessed using data collected from patient medical records: 1. Colonoscopy completion among high-risk participants, defined as the proportion of participants with at least one colonoscopy recorded by the organized screening program, at 1-year follow-up 2. Fecal immunochemical test (FIT) completion among low-risk participants, defined as the proportion of participants with at least one FIT result recorded by the colorectal cancer screening program, at 1-year follow-up 3. Overall screening participation, defined as the proportion of participants with at least one colonoscopy or one FIT recorded by the colorectal cancer screening program, at 1-year follow-up 4. Number needed to scope, defined as the number of colonoscopies performed per advanced neoplasia detected, at 3-year follow-up 5. Overall screening participation by socioeconomic status at 1-year follow-up. This outcome will be calculated in the same way as overall screening participation. Comparisons will be stratified by deciles of the Swiss Socio-Economic Position (Swiss-SEP) score, an address-based, area-level index, to assess whether the intervention's effect on participation varies by socioeconomic position. | — |
Countries
Switzerland
Contacts
Public ContactKevin Selby
Outcome results
None listed