Hypovolemic or septic shock Signs and Symptoms Hypovolaemic shock, septic shock
Conditions
Interventions
The study will involve 55 mechanically ventilated adults with hypovolemic or septic shock. The attending physician clinically determined the need for volume expansion (VE). If patients were treated wi
Amsterdam, the Netherlands) with a 3-5 MHz phased-array probe. M-mode (time-motion) echocardiography was employed at the level of the aortic annulus in a two-dimensional view from the parasternal long
Sponsors
Affiliated Provincial Hospital of Anhui Medical University (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Evidence of inadequate tissue perfusion with acute circulatory failure defined as a systolic arterial pressure of 90 mmHg (or a decrease of 40 mmHg in a patient with hypertension) 2. Urine output below 0.5 ml/kg/h for over 1 h 3. Tachycardia (heart rate < 100/min) 4. Mottled skin 5. Clinical diseases of hypovolemic or septic shock associated with a systemic inflammatory response syndrome 6. Septic shock 7. Controlled massive hemorrhage 8. The attending physician clinically determined the need for volume expansion (VE)
Exclusion criteria
Exclusion criteria: 1. Age < 18 years 2. Moribund 3. Cardiomyopathy 4. Pulmonary edema 5. Increased intracranial pressure 6. Pregnancy 7. Active bleeding 8. Atrial fibrillation 9. Cardiac arrhythmias 10. Myocardial ischemia or infarction within 1 month before the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Cardiac output (CO) 2. Stroke volume (SV) 3. Aortic velocity time index (VTI) 4. Left ventricular ejection fraction (LVEF) | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under the receiver operating characteristic curves (AUC) compared CO variations after 50 ml over 10 s (?CO50) and 500 ml over 15 min (?CO500) and the variation of VTI after infusion of 50 ml fluid over 10 s (?VTI50) | — |
Countries
China
Outcome results
None listed