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The European Alliance Against Depression four-level depression and suicide prevention and wellbeing promotion community intervention focused on vulnerable groups: a study protocol for a prospective, controlled, cross-country design (MentBest)

The European Alliance Against Depression four-level community intervention for depression and suicide prevention and wellbeing promotion focused on vulnerable groups: a study protocol for a prospective, controlled, cross-country design comparing intervention and control regions to reduce suicide attempts, deaths by suicide, and depressive symptoms, and to improve wellbeing (MentBest)

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN10521127
Enrollment
4700
Registered
2026-02-26
Start date
2024-10-28
Completion date
Unknown
Last updated
2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of suicidal behaviour and depression and promotion of wellbeing in the community (general population and vulnerable groups) Mental and Behavioural Disorders

Interventions

Communities in the intervention arm will receive the four-level European Alliance Against Depression (EAAD) community intervention (MentBest), with added components to improve wellbeing and reach vuln

Sponsors

European Alliance Against Depression
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 120 Years

Inclusion criteria

Inclusion criteria: Participants must belong to one of the four study levels: Level 1: Healthcare professionals involved in depression care. Level 2: General population, including the five vulnerable groups: Young people: 15–24 years; Older people: 65+ years, Long-term unemployed, Migrants/refugees and people with an existing mental disorder. Level 3: Community gatekeepers Level 4: People with mild to moderate depression using the iFightDepression® tool. Participants in Level 2 (general population survey) must be 18 years or older. Participants in Level 4 (iFightDepression® tool users) must be 15 years or older.

Exclusion criteria

Exclusion criteria: 1. Individuals under 18 years of age for the general population survey. 2. Individuals under 15 years of age for using the iFightDepression® tool.

Design outcomes

Primary

MeasureTime frame
1. Rate of completed suicides measured using official mortality data from national authorities and suicide registers following WHO ICD-10/11 classifications at baseline (pre-intervention) and 24 months 2. Rate of hospitalizations caused by attempted suicides measured using hospital admission records and suicide registers following WHO ICD-10/11 classifications at baseline (pre-intervention) and 24 months 3. Rate of completed suicides measured using official mortality data from national authorities and suicide registers following WHO ICD-10/11 classifications at the pre-baseline period (2018–2024) and the intervention period (2025–2026) 4. Rate of attempted suicides measured using hospital admission records and suicide registers following WHO ICD-10/11 classifications at the pre-baseline period (2018–2024) and the intervention period (2025–2026)

Secondary

MeasureTime frame
1. Knowledge and attitudes about depression measured using the Personal Stigma Subscale of the Depression Stigma Scale (DSS; Griffiths et al., 2004) and attitudes towards help-seeking using the the Attitudes Towards Seeking Professional Psychological Help-Short Form (ATSPPH-SF; Fischer & Farina, 1995) at baseline (pre-intervention) and 24 months 2. Wellbeing measured using the World Health Organisation Five Well-Being Index (WHO-5; World Health Organisation, 1998) and and depressive and anxiety symptoms using the Patient Health Questionnaire-4 (PHQ-4; Kroenke et al., 2009) at baseline (pre-intervention) and 24 months 3. Competencies of Level 1 and Level 3 trainees measured using the Literacy of Suicide Scale (LOSS; Calear et al., 2022) and the Revised Depression Attitude Questionnaire (R-DAQ; Haddad et al., 2015), at pre-training and immediately post-training, as well as a bespoke satisfaction survey at post-training 4. Depressive symptoms of users of the iFightDepression® tool measured using the Patient Health Questionnaire-9 (PHQ-9, 2001) at registration and six weeks after registration

Countries

Albania, Estonia, Greece, Ireland, Spain

Contacts

Public ContactBridget Hogg
bhogg@researchmar.net+34 933 26 85 00

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026