Improving traumatic brain injury care in Lagos State, Nigeria through adaptation and implementation of evidence-based guidelines

TRAIN: a multiphase mixed-methods implementation study to adapt and implement NICE traumatic brain injury guidelines in Lagos State, Nigeria

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10507371

Enrollment

1500

Registered

2026-03-20

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic brain injury Injury, Occupational Diseases, Poisoning

Interventions

The TRAIN study is a stepped-wedge cluster randomised trial (SW-CRT) conducted across public hospitals in Lagos State, following a formative assessment phase. Clusters (health facilities) are random

Eligibility

Sex/Gender

All

Age

0 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Facilities providing emergency or inpatient traumatic brain injury (TBI) care 2. Healthcare professionals involved in TBI management 3. Patients presenting with TBI (for observational components)

Exclusion criteria

Exclusion criteria: 1. Facilities not providing TBI-related services 2. Individuals unwilling or unable to provide consent where required

Design outcomes

Secondary

Measure	Time frame
1. In-hospital mortality measured using hospital medical records and discharge registers during admission (up to discharge or death) 2. Time to CT imaging measured in minutes from hospital arrival to CT scan using hospital radiology records and emergency department logs during admission 3. Adherence to neuroprotective care protocols measured using a structured clinical audit tool based on predefined protocol indicators, assessed during admission (within the first 72 hours of care) 4. Time to definitive referral measured in hours from presentation to referral decision using clinical case notes and referral documentation during admission 5. Length of hospital stay measured in days from admission to discharge using hospital administrative and clinical records 6. Complication rates (e.g., hypotension, hypoxia, chest infection) measured using patient monitoring charts and clinical records, assessed during admission (up to discharge or death) 7. Health-related quality of life measured using the EQ-5D questionnaire at baseline (or discharge where baseline is not feasible) and 6 months post-injury 8. Cost-effectiveness assessed using incremental cost-effectiveness ratios (ICERs) based on disability-adjusted life years (DALYs) at 6 months, using patient-level cost and outcome data collected during the study	—

Measure

Time frame

1. In-hospital mortality measured using hospital medical records and discharge registers during admission (up to discharge or death) 2. Time to CT imaging measured in minutes from hospital arrival to CT scan using hospital radiology records and emergency department logs during admission 3. Adherence to neuroprotective care protocols measured using a structured clinical audit tool based on predefined protocol indicators, assessed during admission (within the first 72 hours of care) 4. Time to definitive referral measured in hours from presentation to referral decision using clinical case notes and referral documentation during admission 5. Length of hospital stay measured in days from admission to discharge using hospital administrative and clinical records 6. Complication rates (e.g., hypotension, hypoxia, chest infection) measured using patient monitoring charts and clinical records, assessed during admission (up to discharge or death) 7. Health-related quality of life measured using the EQ-5D questionnaire at baseline (or discharge where baseline is not feasible) and 6 months post-injury 8. Cost-effectiveness assessed using incremental cost-effectiveness ratios (ICERs) based on disability-adjusted life years (DALYs) at 6 months, using patient-level cost and outcome data collected during the study

—

Countries

Nigeria

Contacts

Public ContactOlufemi Idowu

olufemi.idowu@lasucom.edu.ng+234 (0)8023451369

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 30, 2026