Healthy adults Nutritional, Metabolic, Endocrine
Conditions
Interventions
A two-arm crossover trial, with 6-week intervention arms and a 4-week washout period. Participants were allocated to a sequence of treatment using an online randomisation tool (https://www.sealedenvel
Sponsors
Food for Health Ireland
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy, not taking medication for cholesterol, blood pressure or digestion 2. Not following a prescribed diet for any reason (weight loss, cholesterol etc) 3. Free from dairy intolerance/allergy and consume an omnivorous diet 4. Male or female, aged 20 - 60 years
Exclusion criteria
Exclusion criteria: 1. Currently taking prescribed medication 2. Following any specific diet will be ineligible for participation in the study 3. Fatty acid/oil-based dietary supplements e.g., fish oils, omega3/6, and other herbal fatty acid-based supplements - e.g., evening primrose oil
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Circulating levels of CLA, n-3 and n-6 fatty acids measured in blood samples by HPLC at baseline and 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Total, HDL and LDL cholesterol, triglyceride and glucose concentrations measured in blood samples using NMR at baseline and 6 weeks 2. Insulin concentrations measured in blood samples using ELISA at baseline and 6 weeks 3. Blood pressure (diastolic and systolic blood pressure) assessed using an electronic blood pressure monitor at baseline and 6 weeks 4. Anthropometry assessed by measuring weight, BMI, body fat % and waist circumference at baseline and 6 weeks 5. Inflammatory markers (hs-CRP, IL2, IL10) assessed by biomarker status at baseline and 6 weeks 6. Antioxidant status (circulating ß-carotene, tocopherol, and retinol) as well as markers of lipid peroxidation biomarker F2-isoprostane assessed by biomarker status at baseline and 6 weeks | — |
Countries
Ireland
Contacts
Public ContactEIleen;Emma GIbney;Feeney
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Outcome results
None listed