Efficacy of glyceryl trinitrate to facilitate the rewarming process during cardiopulmonary bypass

Efficacy of glyceryl trinitrate to facilitate the rewarming process during cardiopulmonary bypass: a prospective randomised trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10480871

Enrollment

100

Registered

2017-08-16

Start date

2017-01-30

Completion date

Unknown

Last updated

2020-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac surgery necessitating CPB Surgery

Interventions

All patients scheduled to undergo cardiac surgery will be reviewed as per usual by the one of the cardiothoracic anaesthesia fellows, both of whom are part of the study team. Patients

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients (aged over 18) 2. Capacity to consent 3. Undergoing cardiac surgery necessitating CPB

Exclusion criteria

Exclusion criteria: 1. Age < 18 years old 2. Allergy to GTN 3. Cardiac surgery necessitation deep hypothermic circulatory arrest (DHCA) 4. Cardiac surgery not involving CPB (eg. off-pump cardiopulmonary bypass grafting) 5. Lack of capacity to consent 6. Use of TIVA propofol whilst on CPB

Design outcomes

Primary

Measure	Time frame
1. Time to completion of rewarming prior to separation from CPB circuit 2. Early post-op patient peripheral – core temperature gradient 3. Time to maintenance of normothermia (core temperature > 36.5°C) for minimum of 2 hours in the initial post-op period and including skin temperature reaching a plateau 4. Plasma lactate concentrations initially post-CPB Nasopharyngeal, skin and bladder temperature are recorded at baseline post induction of anaesthesia, rewarming from CPB, separation from CPB, application of surgical dressing (end of surgery) and arrival in ICU.	—

Measure

Time frame

1. Time to completion of rewarming prior to separation from CPB circuit 2. Early post-op patient peripheral – core temperature gradient 3. Time to maintenance of normothermia (core temperature > 36.5°C) for minimum of 2 hours in the initial post-op period and including skin temperature reaching a plateau 4. Plasma lactate concentrations initially post-CPB Nasopharyngeal, skin and bladder temperature are recorded at baseline post induction of anaesthesia, rewarming from CPB, separation from CPB, application of surgical dressing (end of surgery) and arrival in ICU.

—

Secondary

Measure	Time frame
Time to extubation, measured from application of surgical dressing (end of surgery) to actual time of removal of endotracheal tube (extubation)	—

Countries

Ireland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 17, 2026