Sepsis Infections and Infestations
Conditions
Interventions
Eligible patients will be randomly assigned in a 1:1 ratio to receive either the standard care supplemented with nanoselenium or standard care alone. The random allocation sequence will be generated b
Sponsors
First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years 2. Meet the criteria for sepsis according to the Sepsis-3 definition 3. Expected ICU length of stay > 48 hours 4. Written informed consent obtained from the patient or their legally authorized representative
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women 2. Current use of selenium supplements or known allergy or intolerance to selenium preparations 3. Chronic renal insufficiency requiring regular dialysis 4. Severe hepatic insufficiency (Child-Pugh class C) or acute liver failure 5. Next of kin expressing a wish to withdraw life-sustaining treatment or initiate hospice care 6. Expected survival <3 days 7. Active hematologic malignancy 8. History of organ or bone marrow transplantation 9. History of cardiopulmonary resuscitation (CPR) within 72 hours prior to signing informed consent 10. Inability to obtain informed consent from a legally authorized representative, or explicit refusal to sign informed consent
Countries
China
Contacts
Public ContactWan-Jie Gu
Outcome results
None listed