Do people who have anaphylactic reactions to insect stings or foods have specific forms of genes for hormones involved in controlling blood pressure?

Hymenoptera venom anaphylaxis and food allergy induced anaphylaxis: A study of the renin and angiotensin system

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN10465389

Enrollment

260

Registered

2019-02-13

Start date

1997-04-05

Completion date

Unknown

Last updated

2019-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaphylactic shock Injury, Occupational Diseases, Poisoning

Interventions

The study will be based on patients normally referred to the Allergy Clinic at St Helier Hospital. From their outpatient attendance and assessment, suitable patients will be selected and asked to ma

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Anaphylaxis patients: 1. Wasp- and bee-induced anaphylaxis (>50) or food-induced allergy with anaphylaxis (>50) Control participants: 2. Food allergy without anaphylaxis (>30) or atopic without food allergies (>30) or non-atopic control (>100)

Exclusion criteria

Exclusion criteria: 1. Pregnant 2. Taking drugs that would affect the renin-angiotensin system and levels of blood hormones 3. Involved in any other studies which would be either disadvantageous to the participant's health or the benefit of the study

Design outcomes

Primary

Measure	Time frame
1. Serum ACE level 2. Plasma renin level 3. Plasma angiotensin-1 level 4. Polymorphisms of genes related to the renin angiotensin system including ACE, renin, angiotensinogen (AGT235), chymase CMI-1903, AT-2 receptor	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026