Type 1 diabetes Nutritional, Metabolic, Endocrine Insulin-dependent diabetes mellitus
Conditions
Interventions
Type 1 patients eligible for the study were screened for insulin resistance. Subjects with documented insulin resistance were given 1mg metformin twice daily for three months as an add-on to their ins
Sponsors
Ain-Shams University Research Ethical committee
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: T1DM male subjects = 18 years of age
Exclusion criteria
Exclusion criteria: Subjects with other chronic diseases (such as end-stage liver disease and end-stage renal disease), collagen diseases, malignancies and subjects with any other endocrinopathy (e.g. Cushing’s syndrome and acromegaly) or taking any medications (e.g. thiazide diuretics or steroids) that may affect insulin resistance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of metformin therapy on fetuin level in insulin resistant type 1 diabetics Assessed before assessed before intervention and again at 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Effect of metformin therapy on insulin resistance surrogate (eGDR) 2. Glycemic control (HbA1c%) 3. BMI 4. Weight 5. Insulin dose 6. HsCRP as a marker of cardiovascular risk All assessed before assessed before intervention and again at 3 months. | — |
Countries
Egypt
Outcome results
None listed