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Dry eye and ocular surface parameters after 25 G pars plana vitrectomy

Dry eye and ocular surface parameters after 25 G pars plana vitrectomy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN10442132
Enrollment
50
Registered
2025-08-27
Start date
2021-07-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Evaluation of dry eye after 25G pars plana vitrectomy Eye Diseases

Interventions

All patients underwent 25G pars plana vitrectomy and received the same postoperative regimen: topical moxifloxacin four times daily for one week, and topical prednisolone acetate 1%, tapered over 6–8

Sponsors

Oftamedica
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Consecutive patients over 18 years old who will undergo PPV 25 G by a single surgeon (PM) for Diabetic retinopathy or other causes (i.e. macular hole, epiretinal membrane) 2. Availability to attend Ocular Surface evaluation previous to retinal surgery. 3. Over 18 years old who signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Previous refractive surgery (LASIK/PRK) 2. Patients under glaucoma medication 3. Contact lens wearers 4. Eye surgery in the last 3 months 5. Patients who require conjunctival opening 6. Active inflammation and Inflammatory and autoimmune conditions (I.E Ocular Cicatricial Pemphigoid, Sjoegren Disease)

Design outcomes

Primary

MeasureTime frame
Dry eye symptoms were measured using the Ocular Surface Disease Index (OSDI) at baseline, 1 month, and 3 months

Secondary

MeasureTime frame
1. Tear break-up time and corneal staining (National Eye Institute scale) were assessed at baseline, 1 month and at 3 months 2. Osmolarity (measured in mosm/L) was evaluated at baseline and at 3 months using the TearLab Osmometer 3. Lipid layer thickness (categorized as normal/mild/moderate/severe), non-invasive tear break-up time (measured in seconds), and tear meniscus were assessed at baseline and at 3 months using the Lacrydiag device 4. Evaluation of Conjunctival Impression Citology after small incision Pars Plana Vitrectomy (Nelson Scale and Mucins) at baseline and 3 months after surgery

Countries

Chile

Contacts

Public ContactCristian Cartes
ccartesindo@gmail.com+56 985007180

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026