Patients with knee osteoarthritis who require total knee arthroplasty Musculoskeletal Diseases
Conditions
Interventions
This study aims to compare the analgesic effects of three different administration routes of parecoxib sodium during total knee arthroplasty (TKA). Except for the specific routes described below, all
Sponsors
Luoyang Orthopedic-Traumatological Hospital of Henan Province
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 50–75 years with a primary diagnosis of knee osteoarthritis 2. Patients scheduled for primary, elective, unilateral total knee arthroplasty without clear contraindications to surgery 3. American Society of Anesthesiologists (ASA) physical status classification I–III 4. Willing to participate in the study and able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Body mass index (BMI) >35 kg/m² or body weight 90 minutes), including: prior ipsilateral knee infection, history of complex fracture, previous periarticular osteotomy, massive periarticular bone defect, functional knee stiffness (preoperative maximum range of motion 20°, valgus >15°, or flexion >20°) 6. Participation in another clinical trial within the past 6 months 7. Any surgical procedure within the past 3 months 8. Presence of cognitive impairment or psychiatric disorder that prevents compliance with study assessments
Countries
China
Contacts
Public ContactXiaoya Liu
Outcome results
None listed