Dentine hypersensitivity Oral Health
Conditions
Interventions
Part 1 (clinical study)
Adult participants who report dentine hypersensitivity will be recruited to the study. At screening, participants who have given informed consent will be assess
Sponsors
The Proctor and Gamble Company (USA)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Both part 1 and part 2: 1. At least 18 years of age 2. In good general health 3. Able to follow study procedures 4. Have at least one tooth with a Schiff sensitivity score of 2 in response to a cool air challenge
Exclusion criteria
Exclusion criteria: 1. Severe periodontal disease 2. Active treatment for periodontitis 3. Any medical condition requiring pre-medication prior to dental procedures 4. Any disease or condition that might interfere with the participant completing the study safely 5. Fixed orthodontic appliances 6. A history of kidney stones 7. Self-reported pregnancy or nursing 8. Daily doses of medication that interfere with pain perception such as anti-inflammatory drugs, anti-depressants, sedatives, antihistamines 9. Use of desensitising toothpastes within the 3 months prior to the screening visit 10. Allergy to ingredients in commercial dental products, such as potassium oxalate, potassium sorbate 11. Analgesia within the 8 hours prior to screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part 1: Dentine hypersensitivity as measured by examiner reported Schiff and patient-reported VAS in response to cool air and tactile stimuli. Measured at baseline, after 2 weeks, after 4 weeks Part 2: Tubule occlusion score as determined by assessment of scanning electron microscope images. Measured at baseline and after 2 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Part 1: Participants' perceived dentine hypersensitivity as determined by questionnaire. Measured at baseline, after 2 weeks, after 4 weeks | — |
Countries
United Kingdom
Outcome results
None listed