Atrial fibrillation Circulatory System Atrial fibrillation
Conditions
Interventions
The patients are interviewed on the day of their initial evaluations in the cardiac surgery unit at the Sao Lucas da PUCRS Hospital. They are randomly assigned in a double-blind fashion to begin oral
Sponsors
Sao Lucas da PUCRS Hospital and the Sao Paulo Federal University (Brazil)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Informed consent 2. Older than 18 years 3. Scheduled for exclusive coronary artery bypass graft surgery requiring cardiopulmonary bypass 4. Normal sinus rhythm
Exclusion criteria
Exclusion criteria: Exclusion criteria amended as of 16/11/2007: 1. Patients who are allergic to naproxen or other nonsteroidal anti-inflammatory drugs 2. Patients who are participating in another investigational trial 3. Pregnant women 4. Renal failure 5. History of gastrointestinal bleeding 6. Chronic liver disease 7. Thrombocytopenia (platelets below 50.000/mm^3) 8. Preoperative use of glucocorticoids 9. Previous diagnosis of atrial fibrillation Exclusion criteria provided at time of registration: 1. Patients who are allergic to naproxen or other nonsteroidal anti-inflammatory drugs 2. Patients who are participating in another investigational trial 3. Pregnant women 4. Renal failure 5. History of gastrointestinal bleeding 6. Chronic hepatitis 7. Thrombocytopenia (platelets below 50.000/mm^3)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative atrial fibrillation, determined within 5 days of the patient's coronary artery bypass graft surgery. Atrial fibrillation is counted if it persists for more than three minutes or the patient develops hemodynamic instability. | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall length of hospital stay and length of stay at the intensive care unit. | — |
Countries
Brazil
Outcome results
None listed