Prevention of mandibular lower border defects after bilateral sagittal split osteotomy Surgery
Conditions
Interventions
Patients are randomly allocated to study and control groups by stratified randomisation method using a computer program. Patients know their allocated groups.
Before surgery, peripheral venous blood
Sponsors
Riga Stradinš University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-50 years 2. Patients diagnosed with dentofacial deformities, who were planned to undergo bilateral sagittal split osteotomy 3. A serum vitamin D level of more than 30 ng/ml is considered sufficient thereby patients were included in the study 4. Health condition - without any chronic disease, had no regular medication intake, had no abnormal nicotine or alcohol use
Exclusion criteria
Exclusion criteria: Patients who did not have cone-beam computed tomography 7-12 days and 1 year after surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Presence/absence of inferior border bone defects at the mandible near the vertical osteotomy site measured using CBCT at 1 year after surgery 2. Newly formed bone volume at the site of BSSO vertical osteotomy site measured using CBCT at 7-12 days and 1 year after orthognathic surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Bone resorption/remodelling near the osteotomy site measured using CBCT at 7-12 days and 1 year after surgery 2. Concentration of proteins in i-PRF and their correlation at 1-2 days before surgery: 2.1. EGF (pg/ml) measured using ELISA assay 2.2. VEGF (pg/ml) measured using ELISA assay 2.3. PDGF (pg/ml) measured using ELISA assay 2.4. TGFb1 (pg/ml) measured using ELISA assay 2.5. IL8 (pg/ml) measured using ELISA assay 3. The anti-microbial effect of i-PRF measured using the agar-diffusion method, zone of inhibition (mm) at 1-2 days before surgery | — |
Countries
Latvia
Contacts
Public ContactLana Micko
Outcome results
None listed