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Testing whether an herbal product can reduce gum inflammation when used alongside standard periodontal treatment

Efficacy of a topical polyherbal phytopreparation as an adjunct to scaling and root planing therapy in patients with periodontitis: a randomized controlled clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN10262904
Enrollment
150
Registered
2026-02-20
Start date
2020-10-18
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The efficacy of a polyherbal phytopreparation as an adjunctive therapy to scaling and root planing in patients with periodontitis. Oral Health

Interventions

This study is designed as a randomized controlled clinical trial including 80 adults diagnosed with stage II, grade A periodontitis. After baseline assessment, participants are randomly allocated in a

Sponsors

University of Niš - Faculty of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Adults aged 18 to 65 years. 2. Individuals diagnosed with periodontitis based on medical history and clinical evaluation. 3. Presence of at least 24 natural teeth. 4. Radiographic evidence of bone loss. 5. Periodontal status determined using the 2018 classification of periodontal diseases and conditions. 6. Diagnosis of periodontitis confirmed by either interdental clinical attachment loss at two or more non-adjacent teeth, or buccal/oral clinical attachment loss of 3 mm or more together with periodontal pocket depth of 3 mm or more at two or more teeth. 7. Individuals not meeting the above diagnostic criteria were considered periodontally healthy and therefore not included.

Exclusion criteria

Exclusion criteria: 1. A history of alcohol consumption 2. Tobacco use in any form (past or present) 3. A medical history of anemia 4. Diabetes 5. Hepatitis 6. Tuberculosis 7. AIDS 8. Leukemia 9. Other systemic or hormonal disorders linked to gingival manifestations 10. Those who were undergoing or had previously undergone treatment with systemic hormonal therapy, contraceptive usage, corticosteroids, immunosuppressants, radiation therapy, or chemotherapy before the study started

Countries

Serbia

Contacts

Public ContactDušanka Kitic
dusanka.kitic@medfak.ni.ac.rs+381 62328036

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 14, 2026