Cervical spine dumbbell tumors Cancer
Conditions
Interventions
This study does not involve any direct interventions on patients. The research process involves the following steps:
Retrospective review of medical records and imaging data of adult patients who und
Sponsors
China-Japan Union Hospital of Jilin University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18 years or older at the time of surgery 2. Diagnosed with cervical dumbbell tumor confirmed by MRI 3. Underwent surgical treatment for the tumor between January 1, 2010 and December 31, 2020 4. Complete medical records available, including: 4.1. Preoperative imaging (MRI and/or CT scans) 4.2. Detailed surgical records 4.3. Postoperative follow-up data for at least 12 months 5. Tumor histologically confirmed as one of the following types: 5.1. Schwannoma 5.2. Neurofibroma 5.3. Other nerve sheath tumors 6. Ability to provide informed consent for the use of medical data in research (or appropriate proxy consent if patient is incapacitated) 7. Patients with both primary and recurrent cervical dumbbell tumors are eligible
Exclusion criteria
Exclusion criteria: 1. Patients younger than 18 years at the time of surgery 2. Incomplete medical records or imaging data, including: 2.1. Missing preoperative MRI or CT scans 2.2. Incomplete surgical records 2.3. Less than 12 months of postoperative follow-up data 3. Patients who underwent non-surgical treatment for their cervical dumbbell tumor 4. Patients with a history of previous cervical spine surgery unrelated to the dumbbell tumor 5. Patients with concurrent spinal cord tumors not classified as dumbbell tumors 6. Patients with severe comorbidities that significantly impact neurological function or surgical outcomes, such as: 6.1. Advanced neurodegenerative diseases (e.g., advanced Parkinson's disease, multiple sclerosis) 6.2. Severe spinal deformities 6.3. Active systemic malignancies 7. Pregnant women at the time of surgery 8. Patients unable to provide informed consent for the use of their medical data in research (and no appropriate proxy available) 9. Tumors histologically confirmed to be types other than schwannomas, neurofibromas, or nerve sheath tumors 10. Patients who received preoperative radiotherapy or chemotherapy for the cervical dumbbell tumor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effectiveness of the new scoring and classification system for cervical dumbbell tumors is assessed by its ability to predict surgical outcomes and complications. This is measured by: 1. The correlation between the preoperative tumor score/classification and the extent of surgical resection (complete vs. partial) as determined by postoperative imaging at 3 months post-surgery. 2. The association between the preoperative tumor score/classification and the occurrence of surgical complications, evaluated during the immediate postoperative period and at follow-up visits at 1, 3, and 6 months post-surgery. 3. Inter-observer reliability of the new system, measured using the intraclass correlation coefficient (ICC) for continuous scores and Cohen's kappa for categorical classifications, assessed by independent evaluations from at least three neurosurgeons. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neurological function improvement measured using the Japanese Orthopaedic Association (JOA) score at baseline (preoperative) and at 3, 6, and 12 months postoperatively. 2. Pain reduction assessed using the Visual Analog Scale (VAS) at baseline (preoperative) and at 1, 3, 6, and 12 months postoperatively. 3. Quality of life changes evaluated using the Short Form-36 (SF-36) questionnaire at baseline (preoperative) and at 6 and 12 months postoperatively. 4. Tumor recurrence rate determined by follow-up MRI scans at 12 months and annually thereafter for 5 years post-surgery. 5. Long-term surgical complication rates (e.g., cerebrospinal fluid leakage, wound infection) assessed during follow-up visits at 1, 3, 6, and 12 months postoperatively, and annually thereafter for 5 years. 6. The correlation between tumor location (as classified by the new system) and the surgical approach chosen, analyzed retrospectively from surgical records. 7. Patient satisfaction with surgical outcomes measured using a custom 5-point Likert scale questionnaire at 6 and 12 months postoperatively. | — |
Countries
China
Contacts
Public ContactYONGCHUAN;Fan GUO;Li
;
Outcome results
None listed