Does giving kidney donors intravenous fluids the night before kidney donation make any difference?

A Comparison of the effects of Oral vs INtravenous hydration on Subclinical acute kidney injury: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10199225

Enrollment

Registered

2015-04-20

Start date

2015-01-30

Completion date

Unknown

Last updated

2017-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Live kidney donors Urological and Genital Diseases

Interventions

Patients will be randomly assigned to one of two groups using a computer-generated randomisation schedule. Preoperative Intravenous Fluid Group The evening prior to surgery (day -1), between midnig

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients aged >18 years of age undergoing live donor hand-assisted laparoscopic nephrectomy eligible to participate 2. Consent to participate given 3. English-speaking or appropriate translation facilities to allow for consent to be valid 4. Living donor transplant in Western Infirmary, Glasgow 5. Transplant taking place between dates of the trial

Exclusion criteria

Exclusion criteria: 1. Patients undergoing open nephrectomy 2. Patients unable/unwilling to consent

Design outcomes

Secondary

Measure	Time frame
1. Day 1 change in donor N-GAL from baseline 2. Donor renal function (serum creatinine and eGFR) day 1-4, week 6 and 1 year, as is standard procedure 3. Donor BNP (Day -1, Day 0, Day 1) 4. Recipient change in N-GAL from baseline 5. Recipient serum creatinine and eGFR at 6 weeks and 1 year 6. Delayed graft function (DGF) – defined as use of dialysis in the first week postoperatively 7. 1-year graft and patient survival in recipient 8. Intraoperative haemodynamics (including blood pressure, heart rate, stroke volume, cardiac index and systemic vascular resistance index) and response to fluid challenge 9. N-GAL levels in blood obtained from renal vein during retrieval and implantation surgery 10. Perioperative mortality 11. Perioperative fluid balance 12. Perioperative complications (including cardiorespiratory complications, time to first bowel motion, infective complications, length of hospital stay, readmission) 13. Donor sleep quality	—

Measure

Time frame

1. Day 1 change in donor N-GAL from baseline 2. Donor renal function (serum creatinine and eGFR) day 1-4, week 6 and 1 year, as is standard procedure 3. Donor BNP (Day -1, Day 0, Day 1) 4. Recipient change in N-GAL from baseline 5. Recipient serum creatinine and eGFR at 6 weeks and 1 year 6. Delayed graft function (DGF) – defined as use of dialysis in the first week postoperatively 7. 1-year graft and patient survival in recipient 8. Intraoperative haemodynamics (including blood pressure, heart rate, stroke volume, cardiac index and systemic vascular resistance index) and response to fluid challenge 9. N-GAL levels in blood obtained from renal vein during retrieval and implantation surgery 10. Perioperative mortality 11. Perioperative fluid balance 12. Perioperative complications (including cardiorespiratory complications, time to first bowel motion, infective complications, length of hospital stay, readmission) 13. Donor sleep quality

—

Primary

Measure	Time frame
Day +1 acute kidney injury (as measured by N-GAL)	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 27, 2026