Retained placenta Pregnancy and Childbirth Retained placenta without haemorrhage
Conditions
Interventions
The enrolled participants will be allocated randomly into three groups. The trial allocation sequence for all cases enrolled will be developed using a computer-generated random number table. Sequentia
Sponsors
Al-Hayat National Hospital (Saudi Arabia)
Menoufiya University Hospital (Egypt)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Booked or un-booked patients who deliver in the study hospitals or those who are transferred to them after delivering elsewhere 2. Gestational age of 28 weeks or more (updated 11/08/2015: was previously 20 weeks or more) 3. Singleton pregnancies 4. =30 minutes interval after the delivery of the baby provided that our routine active management of the third stage was implemented
Exclusion criteria
Exclusion criteria: 1. Maternal hemodynamic instability requiring immediate intervention (pulse > 100 beats per minute, systolic blood pressure <100 mmHg, diastolic blood pressure reduction more than 20 mmHg) 2. Severe postpartum hemorrhage requiring immediate intervention 3. History of RP or MROP in any previous delivery 4. Vaginal birth after previous cesarean scar 5. Associated medical disorders (e.g., pre-eclampsia, gestational hypertension, pre-gestational and gestational diabetes, cardiac diseases) 6. Placenta previa in the current pregnancy or previous pregnancies 7. Stillborn baby 8. Snapped umbilical cord 9. Known uterine anomalies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Delivery of the placenta within 30 minutes following drug administration (either spontaneously or following controlled cord traction) 2. The need for MROP | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Post-partum hemorrhage defined as drop in the hemoglobin of 2 g/dl between the pre-randomization level or that taken at least 2 weeks before delivery and the hemoglobin measured 24 hours after delivery 2. Need for blood transfusion at any time before discharge from the hospital 3. Need for additional uterotonic agents to control post-partum hemorrhage 4. Need for uterine curettage | — |
Countries
Egypt, Saudi Arabia
Outcome results
None listed