The AUTOFLOW Study - using data to predict if oxygen levels in the brain and kidneys are likely to become low.

Development of algorithms for the prediction of the limits of autoregulation for cerebral and renal blood flow during major surgery with continuous invasive and non-invasive blood pressure measurements.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN10141428

Enrollment

100

Registered

2022-06-16

Start date

2022-03-17

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of cerebral and renal desaturation in major non-cardiac surgery. Surgery

Interventions

Prior to anaesthetic induction, participants will receive routine invasive haemodynamic monitoring via an arterial line (FloTrac sensor). Additionally, a finger cuff (ClearSight) will be applied to th

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients due to undergo elective major non-cardiac surgery requiring invasive arterial monitoring (decided at the discretion of the treating clinician) under general anaesthesia, and with an expected duration of greater than 90 minutes.

Exclusion criteria

Exclusion criteria: 1. Subject has skin abnormalities affecting the forehead, flank or skin of the upper leg that would prevent monitoring of tissue oxygenation during the study 2. Patients undergoing cardiac surgery with cardiopulmonary bypass (non-pulsatile blood flow) 3. Age <18 years

Design outcomes

Primary

Measure	Time frame
Raw waveform data collected using: 1. Haemodynamic monitoring measured using arterial line (FloTrac sensor) 2. Non-invasive haemodynamic monitoring using finger cuff (ClearSight) 3. Four NIRS sensors (ForeSight) two to the forehead for cerebral oxygenation, one to the right flank for renal oxygenation, and one to the quadriceps for peripheral oxygenation	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

England, Netherlands, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026