Response to Epstein Barr virus (EBV) infection in children undergoing heart transplant Infections and Infestations
Conditions
Interventions
Blood samples assessing EBV status and to investigate systemic immune parameters will be obtained pre-transplant and during two years following transplant.
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Age
0 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Resident in the UK. 2. Aged 0 – 18 years. 3. Actively listed on the NHS Blood and Transplant (NHSBT) waiting list for a primary organ transplant OR awaiting transplant with a living related donor kidney OR recently transplanted with pre-transplant blood samples available. 4. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Has a pre-existing diagnosis of an inherited or acquired immunodeficiency 2. Has an underlying thymic disorder 3. Has previously received a bone marrow or organ transplant 4. Has had a previous cancer diagnosis 5. Withheld consent 6. Weight under 2.5 kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Innate and adaptive immune cell populations will be assessed in peripheral blood samples taken pre-transplant and at 3, 6, 12 and 24 months post-transplant. 2. Peri-transplant EBV-specific immune responses will be assessed in peripheral blood samples taken pre-transplant and at 3, 6, 12 and 24 months post-transplant. | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Outcome results
None listed