Comparison of lung water in COVID-19 patients and other patients with acute respiratory failure

EVALUATION: Extravascular lung water index in patients with COVID-19: A prospective comparison to a recent cohort with non-COVID-19 ARDS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN10077335

Enrollment

Registered

2020-04-07

Start date

2020-03-19

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 (SARS-CoV-2 infection) and acute respiratory distress syndrome (ARDS) Infections and Infestations

Interventions

According to the standard of the ICU for COVID-19 and non-COVID-19 patients, routine data of patients with COVID-19 and ARDS including PiCCO-monitoring will be documented from the day of intubation un

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 or older 2. Critically ill 3. COVID-19 and acute respiratory distress syndrome (ARDS) according to Berlin-Definition 4. No contra-indication to PiCCO-monitoring

Exclusion criteria

Exclusion criteria: 1. Pregnant

Design outcomes

Primary

Measure	Time frame
Extravascular lung water index EVLWI measured using TPTD (PiCCO; Pulsion Medical Systems; Feldkirechen Germany) daily from intubation until extubation	—

Secondary

Measure	Time frame
Measured daily using TPTD from intubation until extubation: 1. Cardiac index CI 2. Preload marker global end-diastolic volume index GEDVI 3. Pulmonary vascular permeability index PVPI	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026