Moderate consumption of a functional wine enriched in polyphenols on markers of metabolic syndrome, antioxidant profile, and oxidative damage

Low-alcohol and low-calorie wines with clinically demonstrated superior antioxidant functionality: development of production strategies and market validation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10066959

Enrollment

Registered

2026-01-26

Start date

2024-08-12

Completion date

Unknown

Last updated

2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Consumption of functional wine enriched with wine polyphenols will contribute to restoring, to a greater extent, cardiometabolic markers and plasma antioxidants, and to reducing oxidative damage in those who consume it, compared to consumption of the same wine without the addition of polyphenols (control wine). Nutritional, Metabolic, Endocrine

Interventions

Men and woman between 30 and 65 years of age, regular red wine consumer, were selected to participate in a randomized controlled intervention study of the effect of a functional wine enriched in red w

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Voluntary acceptance to participate in the study 2. Signed informed consent 3. Male or female between 30 and 65 years of age 4. Regular red wine consumer (= 3 times per week) 5. Wine consumption with an AUDIT (Alcohol Use Disorders Identification Test) score of less than 8 points 6. Individuals who are overweight (body mass index (BMI) between 25 and 35 kg/m2) or who present one of the following components of metabolic syndrome: 6.1. Waist circumference > 90 cm in men or > 80 cm in women 6.2. Blood triglycerides = 150 mg/dl 6.3. Blood HDL cholesterol < 40 mg/dl in men or < 50 mg/dl in women 6.4. High blood pressure = 135/80 mmHg 6.5. Fasting blood glucose = 100 mg/dl Participants who were taking antioxidant supplements and were willing to discontinue use, as well as individuals with pharmacologically controlled hypertension and hypercholesterolemia treated for at least 1 year with lipid-lowering drugs, were accepted into the study.

Exclusion criteria

Exclusion criteria: 1. Obesity with a BMI > 35 kg/m2 2. Presence of:- Diabetes mellitus- Severe dyslipidemia (triglycerides > 500 mg/dl and/or total cholesterol > 300 mg/dl) 3. Active liver disease - Rheumatological or other disease that could alter measurements 4. History of any previous clinical cardiovascular event 5. Use of antioxidant supplements or drugs that could alter the lipid profile 6. Use of psychoactive drugs 7. Possible problematic alcohol use screened for by a score equal to or greater than 8 on the AUDIT (Alcohol Use Disorders Identification Test) questionnaire

Countries

Chile

Contacts

Public ContactInés Urquiaga

iurquiaga@bio.puc.cl+56 998700680

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 15, 2026