Modifying the characteristics of the gums using two different approaches

Clinical comparative study of hyaluronic acid versus I-PRF to modify the gingival phenotype

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10040718

Enrollment

Registered

2021-07-15

Start date

2021-04-01

Completion date

Unknown

Last updated

2023-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thin gingival phenotype Oral Health Disorder of gingiva and edentulous alveolar ridge, unspecified

Interventions

In this split-mouth study, individuals with thin gingival phenotypes were randomly treated with hyaluronic acid and I-PRF. Allocation will be at random using a sequentially numbered opaque, sealed env

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients 2. Gingival thickness of the mandibular anterior teeth >1 mm 3. No pregnancy or lactation 4. Non-smokers

Exclusion criteria

Exclusion criteria: 1. Active orthodontic treatment 2. Previous periodontal surgery 3. Use of any drug that might affect periodontal health 4. Malocclusion, crowding, missing or supernumerary teeth 5. Tooth mobility, bruxism

Design outcomes

Primary

Measure	Time frame
1. Gingival thickness measured using a no.15 endodontic spreader (inserted perpendicularly from the vestibular midpoint 1.5 mm apical of the gingival margin through the soft tissue until a hard surface is reached, with a flowable composite used to mark the reference point) and a digital caliper to assess the penetration depth between the tip and the composite at baseline, 1, and 3 months 2. Keratinized tissue width measured from gingival margin to mucogingival junction with the help of a periodontal probe (UNC 15 probe) at baseline, 1, and 3 months	—

Measure

Time frame

1. Gingival thickness measured using a no.15 endodontic spreader (inserted perpendicularly from the vestibular midpoint 1.5 mm apical of the gingival margin through the soft tissue until a hard surface is reached, with a flowable composite used to mark the reference point) and a digital caliper to assess the penetration depth between the tip and the composite at baseline, 1, and 3 months 2. Keratinized tissue width measured from gingival margin to mucogingival junction with the help of a periodontal probe (UNC 15 probe) at baseline, 1, and 3 months

—

Secondary

Measure	Time frame
1. Plaque index measured using a probe and a mirror to evaluate the plaque accumulation on the tooth at baseline, 1, and 3 months 2. Gingival index measured using a probe and a mirror to evaluate gingival inflammation at baseline, 1, and 3 months 3. Probing depth index measured using a periodontal probe to measure the periodontal pocket depth at baseline, 1, and 3 months 4. Clinical attachment loss (CAL) measured using a periodontal probe from the CEJ Cemento-enamel junction, to the gingival margin at baseline, 1, and 3 months 5. Bleeding on probing (BOP) measured on probing at baseline, 1, and 3 months	—

Measure

Time frame

1. Plaque index measured using a probe and a mirror to evaluate the plaque accumulation on the tooth at baseline, 1, and 3 months 2. Gingival index measured using a probe and a mirror to evaluate gingival inflammation at baseline, 1, and 3 months 3. Probing depth index measured using a periodontal probe to measure the periodontal pocket depth at baseline, 1, and 3 months 4. Clinical attachment loss (CAL) measured using a periodontal probe from the CEJ Cemento-enamel junction, to the gingival margin at baseline, 1, and 3 months 5. Bleeding on probing (BOP) measured on probing at baseline, 1, and 3 months

—

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026