Skin sensitisation and allergic contact dermatitis in persons occupationally exposed to epoxy resins Skin and Connective Tissue Diseases
Conditions
Interventions
Primary Intervention:
Improvements in the detection of skin contamination with epoxy resins using UV light systems.
Secondary Intervention:
Improvements in worker education and risk communication
Co
Sponsors
Project INTERCAMBIO
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participant is able to read and understand briefing materials, participant information sheets, voluntary informed consent or survey forms provided in English, Danish, Spanish or Portuguese 2. Participant is willing and able to give informed consent for participation in the study 3. Participant has direct employment in WTB production at the manufacturing facility, i.e. is not employed via a contractor 4. Aged 18 to 70 years 5.1. Either performs tasks involving the application of uncured epoxy resin to be recruited as an exposed production worker 5.2. Or performs any other tasks relating to the production on the factory floor, e.g. delivering goods and materials, transporting products, or preparing composite materials in moulds, to be recruited as a non-exposed production worker
Exclusion criteria
Exclusion criteria: 1. Specifically concerning patch-testing: 1.1. Participant is taking more than 10 mg oral prednisolone daily for any condition 1.2. Participant is on any other form of immunosuppressive therapy 1.3. Participant has previously been diagnosed with occupational, contact or atopic dermatitis of the hands/forearms 2. Specifically concerning post-intervention patch testing: 2.1. Participant has produced a skin response suggesting sensitisation at baseline during this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin sensitisation status assessed using skin patch testing at baseline and 6 to 12 months post-intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Self-reported symptoms of hand and forearm eczema measured using the Nordic Occupational Skin Questionnaire (NOSQ) at baseline and 6 to 12 months post-intervention 2. Self-reported effects of eczema on daily life measured using the NOSQ at baseline and 6 to 12 months post-intervention 3. Self-reported well-being measured using the World Health Organisation 5 Well-Being Index at baseline and 6 to 12 months post-intervention 4. Self-reported depressive symptoms measured using the Center for Epidemiologic Studies Depression scale at baseline and 6 to 12 months post-intervention 5. Self-reported health measured using the Self-rated Health question at baseline and 6 to 12 months post-intervention 6. Self-reported productivity loss measured using the PROductivity and DISease Questionnaire (PRODISQ) at baseline and 6 to 12 months post-intervention | — |
Countries
Denmark, Portugal, Spain
Contacts
Public ContactAlexander Gorny
Outcome results
None listed