Digestibility of broad bean (faba bean) protein compared to whey protein

Effect of faba bean protein versus whey protein on human metabolic responses: a single-blind, randomised, acute crossover study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN10030424

Enrollment

Registered

2025-06-11

Start date

2024-03-05

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This is an acute feeding study in healthy adults Other

Interventions

Participants will complete four acute interventions (two tests, as shown below) in a random order (randomisation was carried out using a computer programme) with at least a one-week washout between st

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 18-40 years old 2. Body mass index (BMI) = 18.5 kg/m2 and/or weight =50kg 3. Be willing to consume a drink with whey protein and fava bean protein 4. Be available to meet the requirements of the study (i.e. attend study visit, give blood samples)

Exclusion criteria

Exclusion criteria: 1. Pregnancy or lactating 2. Any known food allergy or intolerance, including lactose intolerance or milk allergy 3. Known history of diabetes mellitus or the use of antihyperglycemic drugs or insulin to treat diabetes and related conditions 4. Medical condition or medication known to affect glucose regulation or appetite and/or digestion and absorption of nutrients 5. Major medical or surgical event requiring hospitalisation in the three months preceding the first visit 6. Use of steroids, protease inhibitors or antipsychotics 7. Donated blood to the NI Blood Transfusion Service in the last 12 weeks for men or 16 weeks for women

Design outcomes

Primary

Measure	Time frame
Circulating concentrations of GLP-1 measured using a Mesoscale Discovery (MSD) analyser in plasma blood samples at T0 (before the drink is consumed), T30, T60, T90 and T120 (minutes)	—

Secondary

Measure	Time frame
Circulating concentrations of the following molecules in plasma blood samples at T0 (before the drink is consumed), T30, T60, T90 and T120 (minutes): 1. Other satiety hormones (C-Peptide, GIP, glucagon, insulin, leptin and PYY) measured using a Mesoscale Discovery (MSD) analyser 2. Glucose measured using a glucose oxidase analyser 3. Amino acids measured using a triple-quadrupole mass spectrometer 4. Targeted metabolites measured using a commercially available metabolomics profiling kit	—

Measure

Time frame

Circulating concentrations of the following molecules in plasma blood samples at T0 (before the drink is consumed), T30, T60, T90 and T120 (minutes): 1. Other satiety hormones (C-Peptide, GIP, glucagon, insulin, leptin and PYY) measured using a Mesoscale Discovery (MSD) analyser 2. Glucose measured using a glucose oxidase analyser 3. Amino acids measured using a triple-quadrupole mass spectrometer 4. Targeted metabolites measured using a commercially available metabolomics profiling kit

—

Countries

Northern Ireland, United Kingdom

Contacts

Public ContactEleni Spyreli

Eleni.Spyreli@qub.ac.uk-

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026